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KMID : 0928320170170020047
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Korean Journal of Health Promotion and Disease Prevention
2017 Volume.17 No. 2 p.47 ~ p.53
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Serum Ferritin Levels Are Associated with the Higher Risk of Diabetes Mellitus in Men and Post-menopausal Women, Based on the 2010-2012 KNHANES
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Kim Joo-Yeon
Kang Hee-Taik
Lee Yong-Jae
Kim Jin-Young
Kim Tae-Jong
Lim Hyoung-Ji
Lee Jae-Woo
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Abstract
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Background: The aim of this study was to investigate the relationship between serum ferritin and diabetes mellitus (DM) in the Korean population.
Methods: This cross-sectional study included 9,576 subjects (4,264 men, 2,394 pre-menopausal women, and 2,918 post-menopausal women) older than 19 years using data from the 2010-2012 Korean National Health and Nutrition Examination Survey. DM was defined as fasting plasma glucose ≥126 mg/dL, glycosylated hemoglobin ≥6.5%, or use of any glucose-lower medication including insulin therapy.
Results: The overall prevalence of DM was 12.0, 3.6, and 17.3% in men, pre-menopausal women, and post-menopausal women, respectively. DM prevalence was greater with ferritin levels from Q1 to Q4: 10.3, 10.2, 12.7, and 14.8% in men; 2.0, 2.8, 2.8, and 6.4% in pre-menopausal women; and 13.9, 14.4, 18.1, and 22.9% in post-menopausal women, respectively. Compared with participants in Q1, the odds ratios (95% confidence intervals) for DM among participants in Q4 were 1.67 (1.20- 2.32) in men, 2.06 (0.91-4.66) in pre-menopausal women, and 1.60 (1.09-2.35) in post-menopausal women after adjusting for age and other covariates.
Conclusion: Serum ferritin concentration was positively associated with a higher risk of DM in adult men and post-menopausal women.
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KEYWORD
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Diabetes mellitus, Ferritin, Insulin resistance
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